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Our evaluation of the cohort is that the medical exercise of MCLA-129 in second line head and neck cancer seems significantly inferior to that of our lead asset petosemtamab, and only on par with other EGFR or cetuximab-based mostly monoclonal or bispecific antibodies as monotherapy in an analogous setting. We feel this efficacy is inadequate to warrant further growth in head and neck most cancers.

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MCLA-129 is built to have two complementary mechanisms of motion: blocking development and survival pathways to halt tumor expansion and recruitment and enhancement of immune effector cells to do away with the tumor.